Interleukin-18: Biological properties and role in disease pathogenesis
نویسندگان
چکیده
منابع مشابه
Exploring the role of Th1 cytokines: interleukin-17 and interleukin-18 in periodontal health and disease.
There are conflicting data regarding the role of interleukin (IL)-17 in periodontal health and disease. However, IL-18 levels are known to increase with the severity of periodontal disease. The present study was performed to explore the role of these proinflammatory cytokines in periodontal disease progression, and also to clarify the effect of periodontal treatment on their concentration. Sixt...
متن کاملRole of interleukin 15 and interleukin 18 in inflammatory response.
Interleukin 15 (IL15) and interleukin 18 (IL18) are cytokines produced principally by macrophages during innate immune response and subsequently profoundly influence adaptive immunity. Recent studies have shown that IL15 and IL18 play an influential part in inflammatory response. Here we present recent data mainly from our own laboratories illustrating the importance of IL15 and IL18 in the ind...
متن کاملRole of interleukin 18 in rheumatoid arthritis.
These include: References http://ard.bmjjournals.com/cgi/content/full/62/suppl_2/ii48#BIBL This article cites 19 articles, 14 of which can be accessed free at: Rapid responses http://ard.bmjjournals.com/cgi/eletter-submit/62/suppl_2/ii48 You can respond to this article at: service Email alerting top right corner of the article Receive free email alerts when new articles cite this article sign u...
متن کاملGenetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease.
BACKGROUND Interleukin (IL)-18 plays a key role in atherosclerosis and its complications. The present study investigated the genetic variability of 4 genes of the IL-18 system-IL18, IL18R1, IL18RAP, and IL18BP-in relation to circulating IL-18 levels and cardiovascular mortality. METHODS AND RESULTS Twenty-two polymorphisms were genotyped in 1288 patients with coronary artery disease prospecti...
متن کاملInterleukin 18 and interleukin 18 binding protein: possible role in immunosuppression of chronic renal failure.
Although interleukin (IL)-18 is a member of the IL-1 family of ligands, IL-18 appears to have unique characteristics, particularly in the regulation of the T helper type 1 (Th1) response. Th1 responses are required for tumor surveillance, killing intracellular organisms, and to provide help for antibody production. In patients with chronic renal failure, the well-known immunosuppression contrib...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2017
ISSN: 0105-2896
DOI: 10.1111/imr.12616